Subsequent studies demonstrated similar postoperative performance after implantation between children with AN and those with sensorineural hearing loss (SNHL). reported the earliest attempts of using CIs for AN, and demonstrated limited efficacy. However, evidence from animal experiments has shown that CIs can restore synchronization through electrical stimulation. However, as the mechanism of AN is not well understood, there is debate concerning the benefits of cochlear implants (CIs) in children with this type of hearing loss.Ĭochlear implantation used to be contraindicated for AN due to its association with nerve degeneration secondary to processes such as demyelination and axon impairment. Cochlear implantation is now recognized as the most promising intervention for improving audibility and speech communication in individuals with AN. According to the currently available clinical evidence, medication and acoustic amplification have limited benefits. Great challenges exist in the treatment of AN. The incidence of AN among hearing-impaired neonates is approximately 10% or higher. AN may involve the inner hair cells, ribbon synapses, and the stem of cranial nerve VIII. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper.įunding: This work was supported by grants from the National Basic Research Program of China (973 Program) (#2012CB967900), Science and Technology Innovation Nursery Foundation of PLA General Hospital (12KMM29), and Clinical Research Supporting Foundation of PLA General Hospital (2012FC-TSYS-3056).Ĭompeting interests: The authors have declared that no competing interests exist.Īuditory neuropathy (AN) is a recently recognized hearing disorder primarily characterized by disrupted auditory nerve synchronization, intact outer hair cell function, and poor speech recognition. Received: JAccepted: ApPublished: May 26, 2015Ĭopyright: © 2015 Ji et al. PLoS ONE 10(5):Īcademic Editor: Fan-Gang Zeng, University of California, Irvine, UNITED STATES (2015) Determination of Benefits of Cochlear Implantation in Children with Auditory Neuropathy.
Citation: Ji F, Li J, Hong M, Chen A, Jiao Q, Sun L, et al.
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